Phytochemistry – Creating the best All Natural First-aid products for wound care.

What is phytochemistry?

Phytochemistry is the chemistry of plants and the study of phytochemicals, plant processes , and plant products

Centella Asiatica has gained worldwide popularity among the cosmetic and pharmaceutical companies due to its special properties. Centella’s technology and products are based on Centella Asiatica, which is recognized in the Homeopathic Pharmacopoeia of the United States(HPUS).  The plant is native to humid areas of the Austral Hemisphere (Ceylon, India, Madagascar, and Malaysia).

  • The healing properties related to Centella Asiatica have been known for thousands of years. In Africa, the raw plant has been used to cure syphilis and treat open and infected wounds. Chinese physicians used it in tea to treat fevers, colds, and influenza. 
  • Centella Asiatica was the original treatment for leprosy. 

What is Hydrocotyle Asiatica?

Hydrocotyle Asiatica is an extract obtained from the maceration process of Centella Asiatica. Centella Asiatica contains two well-known and clinically documented natural substances that aid the healing process: 

  • Asiaticoside
  • Madecassic acid

These two substances are known as “cicatrizing agents.

Asiaticoside and madecasside, have been clinically demonstrated to:

  • boost circulation
  •  improve the collagen foundation of the skin
  •  fight oxidation to improve skin firmness and elasticity
  •  fight ulcerated skin
  • Reduce keloid formation.

  These active ingredients have been used on post-operative and trauma scars to promote healing and prevent the formation of excess scar tissue.

Hydrocotyle Tincture

The hydrocotyle that contains the active chemical is extracted by a maceration process of leaves and roots of the Centella Asiatica plant. This yields what is known as the base tincture. 

Active ingredients: Centella Asiatica triterpenes Asiatic acid and madecassic acid, together with two triterpenoid ester glycosides:

  1. Asiaticoside
  2. Brahminoside

Extracted from the plant provide modulating properties- improve the synthesis of collagen and other tissue proteins by modulating the action of fibroblasts in the vein wall and stimulating collagen remodeling in and around the venous wall. 

The triterpenoids stimulate the production of collagen and assist in the healing of wounds (Ref. Van Wyk, B and Wink, M Medical Plants – Briza Publications, 2004. ISBN 1 875093 443)

 Saponins prevent excessive scar formation by modulating and slowing the excessive production of the collagen that makes connective tissues at the wound site and increases the concentration of antioxidants in the wounds. 

  • Various clinical studies confirm that Hydroctyle Asiatica is effective in treating surgical wounds, skin grafts, and gangrene.

 It is also effective for traumatic:

  • Traumatic injuries
  • Burns
  • Chronic skin issues
    • Lesions, ulcers, and leprosy wounds

Additional clinical studies have demonstrated that asiaticoside significantly improves wounds healing. (Ref. Shuka, A. et al.: in vitro and in vivo wound healing activity of asiaticoside isolated from Centella Asiatica. Journal of ethnopharmacology 1999; 65:1-11; Bosse JP et al. Clinical study of a new antikeloid agent. Ann Plastic Surg 1979 3:13-21; Morriset R et al. Evaluation of the healing properties of Hydrocotyle Tincture in the treatment of wounds. Phytother Res 1987; 1:117).

In summary, Centella Asiatica and its extract Hydrocotyle Asiatica, which contains the active ingredients asiaticoside and madecasside, have clinical effectiveness and have been used and applied to:

  • Healing wounds
  • Eczema
  • Psoriasis
  • Promoting skin health
  • Improving circulation in general(an important part of wound healing)
  • Sunburs/artificial burns
Centella LLC | Palm Beach Gardens, Florida, 33418
About Centella LLC

Centella LLC specializes in plant-based chemistry for the wound management market. Centella's mission is to develop, manufacture, and commercialize plant-based pharmaceutical products for the wound-healing market.

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